MarketPlace: Proposals

A listing of Solicitations/Requests for Proposals posted by individuals, government or companies.

Title :	Approaches to Assessing Potential Food Allergy from Genetically Engineered Plants
Industry :	Research
Solicitor :	EPA
Funds Avaliable :	0 - 425000
Project Description :	The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is issuing this request for applications (RFA) for applied research on innovative or improved methods to predict whether or not a pesticide protein is a food allergen. Research to characterize the key factors that influence human immune responses to dietary proteins is needed in order to better assess potential food allergy from genetically engineered plants. Proposals are requested on the role of dose, route of sensitization, and/or the physicochemical properties of ingested proteins and their influence on the development of immune sensitization, oral tolerance, or the elicitation of allergic symptoms. Also of interest is how the food matrix and gastrointestinal environment in which proteins are ingested may affect these immune responses. The overall aim of the research program is to improve safety assessment for genetically engineered plants by enhancing the ability to estimate the potency of unknown proteins relative to known allergenic and non-allergenic proteins. Because there is no single, definitive test for determining the allergenic potential of novel pesticide proteins in the diet, risk assessment associated with the regulation of foods derived from modern biotechnology currently uses a “weight-of-evidence” approach. The research will contribute to improved methods for assessing the potential dietary allergenicity of pesticide proteins in genetically engineered plants. Award Information: Anticipated Type of Award: Grant Estimated Number of Awards: Approximately 4 awards Anticipated Funding Amount: Approximately $1.7 million total for all awards Potential Funding per Award: Up to a total of $425,000, including direct and indirect costs, with a maximum duration of 3 years. Cost-sharing is not required. Proposals with budgets exceeding the total award limits will not be considered. Eligibility Information: Public nonprofit institutions/organizations (includes public institutions of higher education and hospitals) and private nonprofit institutions/organizations (includes private institutions of higher education and hospitals) located in the U.S., state and local governments, Federally Recognized Indian Tribal Governments, and U.S. territories or possessions are eligible to apply. See full announcement for more details.
Additional Requirement :	Funding Opportunity Number: EPA-G2009-STAR-H1 Catalog of Federal Domestic Assistance (CFDA) Number: 66.509 Solicitation Opening Date: October 2, 2009 Solicitation Closing Date: January 7, 2010, 11:59:59 pm Eastern Time The full application must be submitted electronically via e-mail to 2009-Biotech-APPS@epa.gov (or through any authorized alternate submission methods described below) by the solicitation closing date and time. All necessary forms are available at http://epa.gov/ncer/rfa/forms/.
Type of Work :	Permanent
Posting Date :	2009-10-21
Contact :	Eligibility Contact: William Stelz (stelz.william@epa.gov); phone: 202-343-9802 Electronic Submissions: Ron Josephson (josephson.ron@epa.gov); phone: 202-343-9643 Technical Contact: Susan Laessig (laessig.susan@epa.gov); phone: 202-343-9617

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